1258 Topical 2-mercaptonicotinoyl glycine (2-MNG): Anti-pigmentation performance versus recognized standards through bayesian meta-analysis in networks

Introduction: Hyperpigmentation disorders (HPD) are a frequent reason for dermatology consultations as they can impair quality of life. The most HPD melasma, post-inflammatory hyperpigmentation and solar lentigos with increased melanin content on top other pathophysiologic features. development an efficient safe ingredient to manage facial skin tone heterogeneities is great importance. Objectives: To evaluate the anti-pigmentation efficacy 2-MNG in preventing UV-induced pigmentation Chinese skin. Methods: Ten studies were conducted women (20-50y). For each study, 30 volunteers phototype III recruited. Several products applied (4mg/cm2) mini zones back, randomized blinded protocol, five days week seven weeks. During second week, exposed 0.5MED UV-daylight during 4 consecutive days. Assessments performed using Chromameter erythema scales. All under exactly same conditions validated vitamin C 7% standard pivot. A Bayesian meta-analysis established large comparison performance versus 19 recognized actives (i.e. Kojic acid, Phenylethyl Resorcinol, Baicalin, Ellagic Resveratrol, Ascorbyl glucoside, 4-butyl-resorcinol, Niacinamide). Results: 0.5% showed significant vehicle. that provides statistically superior compared all selected standards. Conclusions: This new highly marketed active ingredients. It promising approach allowing develop dermocosmetic targeting concerns.